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KMID : 1084220160230030193
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Journal of Rheumatic Diseases
2016 Volume.23 No. 3 p.193 ~ p.197
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Successful Treatment of Newly Developed, Intractable Digital Ulcers and Gangrene with Bosentan in Systemic Sclerosis
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Tag Hee-Sang
Jun Sung-Min
Lee Seung-Geun
Park Eun-Kyoung
Koo Dong-Wan
Kim Geun-Tae
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Abstract
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In systemic sclerosis, digital ulcers and gangrene are somewhat common clinical characteristics of obliterative vasculopathy. These manifestations increase morbidities, such as pain, infections, and acroosteolysis. However, patient responses to the appropriate treatments are often inadequate. We treated a patient with systemic sclerosis who had a refractory digital ulcer and gangrene with bosentan, an endothelin receptor antagonist, and observed improvement. Here we systematically review this case.
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KEYWORD
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Bosentan, Systemic scleroderma, Gangrene
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